Boronic acid derivatives
Cayman Chemical CAY10462 Fatty Acids and Deriv
A selective inhibitor of the 20-HETE synthase CYP4A11 (IC50 = 8.8 nM in human renal microsomes); 200-fold less potent as an inhibitor of 1A, 1C, and 3A CYP450 enzymes
Cayman Chemical 17 RHETE Fatty Acids and Deriv
An isomer of a CYP450 metabolite of arachidonic acid that has no effect on proximal tubule ATPase activity.
Cayman Chemical CAY10434 Fatty Acids and Deriv
A selective inhibitor of the 20-HETE synthase CYP4A11 (IC50 = 8.8 nM human renal microsomes)
Cayman Chemical CAY10562 Fatty Acids and Deriv
A S-nitrosothiol that acts as an NO donor under acidic conditions; decomposes with a half-life of 6 minutes in 0.1 M phosphate buffer, pH 5.0, at 37°C; relaxes phenylephrine-constricted rat aortic strips 35% and 8% at pH 6.0 and 7.4, respectively
Cayman Chemical 16 SHETE Fatty Acids and Deriv
An inhibitor of proximal tubule ATPase activity; a minor CYP450 metabolite of arachidonic acid
Cayman Chemical CAY10443 Fatty Acids and Deriv
A pro-apoptotic activator of the apoptosome; activates caspase-3 (EC50 = 5 µM) in a cell-free assay
Sigma Aldrich Fine Chemicals Biosciences 3-Pyridinylboronic acid >=95.0% | 1692-25-7 | MFCD00674177 | 1G
3-Pyridinylboronic acid >=95.0% | Purity: >=95.0% | Mol Wt: 122.92 | 1692-25-7 | MFCD00674177 | 1G
Cayman Chemical 17 SHDHA Fatty Acids and Deriv
A hydroxy fatty acid formed from DHA by 15-LO and is a precursor to 17(S)-resolvins; inhibits platelet 12-LO (IC50 = 0.4 μM); inhibits TNF-α-induced expression of IL1B in a human glial cell line (IC50 = ~0.5 nM); inhibits NLRP3 inflammasome formation induced by homocysteine in podocytes at 100 nM
Cayman Chemical CAY10573 Fatty Acids and Deriv
A PPAR agonist that displays potent binding at PPARα, γ, and δ (IC50s = 113, 50, 223 nM, respectively) and potently transactivates PPARα, γ, and δ (EC50s = 8, 70, 500 nM, respectively); demonstrates stronger binding and functional activity for PPARγ than rosiglitazone
Cayman Chemical 8 9EpETE Fatty Acids and Deriv
An epoxygenase pathway product produced from EPA by CYP450 both in vitro and in vivo
Cayman Chemical CAY10602 Fatty Acids and Deriv
A SIRT1 activator; inhibits LPS-induced TNF-α release in THP-1 cells at 20 and 60 µM; decreases the expression of GPX4, SLC7A11, and SLC3A2, as well as increases the levels of iron and MDA, in A549, MDA-MB-231, and Hs 578T cells at 5 µM; reduces oleic acid-induced apoptosis and lipid accumulation in HepG2 cells when used at a concentration of 20 µM
Cayman Chemical CAY10486 Fatty Acids and Deriv
An inhibitor of ACAT; inhibits human ACAT-1 and ACAT-2 (IC50s = ~60 µM for both); inhibits copper-mediated oxidation of LDL by about 20% at 3 µM
Cayman Chemical KT 5720 Inhibitors
A potent inhibitor of PKA; blocks PKA signaling through competitive inhibition of ATP (Ki = 60 nM); inhibits phosphorylase kinase, PDK1, MEK, MSK1, PKBα, and GSK3β